![]() Pre-operative color Doppler ultrasound was used to classify cardiac Infective endocarditis and 13 with congenital cardiomyopathy. TheĬohort included 187 patients with rheumatic heart disease, 13 with Ranging from 57 to 73 years and a mean age of 65.7☖.4 years. These patients, 70 were males and 143 were females with an age Selected as research subjects and retrospectively analyzed. January 2010 and May 2013 and met the inclusion criteria were Replacement at Linyi Central Hospital (Linyi, China) between In the present study, 213 patients who receivedĪnti-coagulation treatment with warfarin after cardiac valve However, the dosage of warfarin and the optimal INR value afterĬardiac valve replacement in the elderly patients have remainedĮlusive, which was therefore investigated in the present study. To reflect the degree of blood agglutination in patients, providingĪ basis for clinicians to propose treatment plans for patients. Preferable clinical indicators of anti-coagulant effects are able Prothrombin time (PT) and international normalized ratio (INR) as However, excessive or insufficientĪnti-coagulant effects may cause severe clinical symptoms. Treatment with warfarin, the synthesis of coagulation factors wasĮffectively inhibited by >40% ( 9). Vitamin K cyclase, which is the most commonly used asĪnti-coagulant drug for patients after cardiac valve replacement Warfarin effectively inhibits the synthesis of ![]() To adhere to anti-coagulant therapy after replacement. Patients worldwide undergo cardiac valve replacement due toĭiseases including rheumatic heart valves and degenerative valves Was as high as 57.5 and 59.9%, respectively. Survival rate following biological and mechanical valve replacement Study, that the mean follow-up time was 10.8 years, and the 15-year Chikwe et al ( 5) determined, in a long-term follow-up Important role in the treatment of advanced cardiac valve disease Artificial cardiac valve replacement hasĮffectively improved the life quality of patients and has an Valve structure caused by rheumatic fever, which leads to aĭisorder of cardiac hemodynamics and impairs the quality of life ofĪffected patients as well as posing a threat to their lives INR monitoring is recommended to ensure the safety of the anti‑coagulant drug warfarin, but further study is still required to determine a reasonable target INR value.Ĭardiac valve disease is basically an abnormal heart The dosage of warfarin, the PT and the INR in the hemorrhage group were all significantly greater than those in the normal group and the embolism group (all P<0.05). The average dosage of warfarin was 2.0☐.6, 3.1☐.7 and 1.7☐.6 mg/day in the normal, hemorrhage and embolism groups, respectively. A total of 31 cases (14.6%) developed adverse reactions and complications during the medication period, including 21 cases with hemorrhage (9.9%, hemorrhage group) and 10 cases with embolism (4.7%, embolism group), while 182 patients did not (85.4%, normal group). The warfarin dosage, prothrombin time (PT) and INR were compared among patients with hemorrhage or embolism, and those with no complications. The clinical data of 213 patients who underwent cardiac valve replacement at Linyi Central Hospital (Linyi, China) between January 2010 and May 2013 were retrospectively analyzed. The current study aimed to further explore the INR value of the anti‑coagulation drug warfarin after cardiac valve replacement. Thus far, the target value for international normalized ratio (INR) has remained to be determined.
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